CDK11 antibody (AA 1-130)

Catalog No. ABIN7266578

The Rabbit Polyclonal anti-CDK11 antibody has been validated for IHC and IF. It is suitable to detect CDK11 in samples from Human.

Quick Overview for CDK11 antibody (AA 1-130) (ABIN7266578)

Target: CDK11 (CDK11B) (Cyclin-Dependent Kinase 11B (CDK11B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK11 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CDK11 Antibody

Binding Specificity: AA 1-130

Purpose: CDK11B Rabbit pAb

Sequence: MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK HARVKEKERE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CDK11B (NP_277021.2).

Isotype: IgG

Application Details

Application Notes: IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CDK11

Target: CDK11 (CDK11B) (Cyclin-Dependent Kinase 11B (CDK11B))

Alternative Name: CDK11B

Background: This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants.,CDK11B,CDC2L1,CDK11,CDK11-p110,CDK11-p46,CDK11-p58,CLK-1,PITSLREA,PK58,p58,p58CDC2L1,p58CLK-1,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,Cyclins,CDK11B

Molecular Weight: 49-92kDa

Gene ID: 984

UniProt: P21127

Pathways: Regulation of Lipid Metabolism by PPARalpha, M Phase