Dynamitin antibody (AA 280-401)

Catalog No. ABIN7266851

The Rabbit Polyclonal anti-Dynamitin antibody has been validated for WB. It is suitable to detect Dynamitin in samples from Human.

Quick Overview for Dynamitin antibody (AA 280-401) (ABIN7266851)

Target: Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamitin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Dynamitin Antibody

Binding Specificity: AA 280-401

Purpose: DCTN2 Rabbit pAb

Sequence: VLDQVEARLQ SVLGKVNEIA KHKASVEDAD TQSKVHQLYE TIQRWSPIAS TLPELVQRLV TIKQLHEQAM QFGQLLTHLD TTQQMIANSL KDNTTLLTQV QTTMRENLAT VEGNFASIDE RM

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 280-401 of human DCTN2 (NP_006391.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Dynamitin

Target: Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))

Alternative Name: DCTN2

Background: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.,DCTN2,DCTN50,DYNAMITIN,HEL-S-77,RBP50,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cytoskeleton,Motor Proteins,Neuroscience,Neurodegenerative Diseases,DCTN2

Molecular Weight: 44kDa

Gene ID: 10540

UniProt: Q13561

Pathways: M Phase, Ribonucleoprotein Complex Subunit Organization