EIF4G1 antibody (pSer1108)

Catalog No. ABIN7267045

This Rabbit Polyclonal antibody specifically detects EIF4G1 in WB. It exhibits reactivity toward Human.

Quick Overview for EIF4G1 antibody (pSer1108) (ABIN7267045)

Target: EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF4G1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EIF4G1 Antibody

Binding Specificity: pSer1108

Purpose: Phospho-EIF4G1-S1108 Rabbit pAb

Sequence: GGSGA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic phosphorylated peptide around S1108 of human EIF4G1 (NP_001181875.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EIF4G1

Target: EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1))

Alternative Name: EIF4G1

Background: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.,EIF4G1,EIF-4G1,EIF4F,EIF4G,EIF4GI,P220,PARK18,Epigenetics & Nuclear Signaling,RNA Binding,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,PI3K-Akt Signaling Pathway,Immunology & Inflammation,Akt downstream targets,Protein phosphorylation,EIF4G1

Molecular Weight: 154kDa/158kDa/166kDa/171kDa/175kDa/176kDa

Gene ID: 1981

UniProt: Q04637