FGD5 antibody (AA 1000-1200)

Catalog No. ABIN7267286

The Rabbit Polyclonal anti-FGD5 antibody has been validated for WB. It is suitable to detect FGD5 in samples from Human.

Quick Overview for FGD5 antibody (AA 1000-1200) (ABIN7267286)

Target: FGD5 (FYVE, RhoGEF and PH Domain Containing 5 (FGD5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGD5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGD5 Antibody

Binding Specificity: AA 1000-1200

Purpose: FGD5 Rabbit pAb

Sequence: YLGLLSENCL HSPRLAAAVR EFEQSVQGGS QTAKHRLLRV VQRLFQYQVL LTDYLNNLCP DSAEYDNTQG ALSLISKVTD RANDSMEQGE NLQKLVHIEH SVRGQGDLLQ PGREFLKEGT LMKVTGKNRR PRHLFLMNDV LLYTYPQKDG KYRLKNTLAV ANMKVSRPVM EKVPYALKIE TSESCLMLSA SSCAERDEWY G

Cross-Reactivity: Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human FGD5 (NP_689749.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FGD5

Target: FGD5 (FYVE, RhoGEF and PH Domain Containing 5 (FGD5))

Alternative Name: FGD5

Background: FGD5 (or ZFYVE23) is an endothelial specific gene, plays a crucial role in vascular pruning. Deficient expression of FGD5 markedly inhibits neovascularization, indicated by in vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model. FGD5-deficient endothelial cells fail to migrate. Moreover, the cells are susceptible to proapoptotic stimuli associated with VEGF-stimulated activation of Akt. FGD5 promotes apoptosis-induced vaso-obliteration via induction of the hey1-p53 pathway by direct binding and activation of CDC42.,FGD5,ZFYVE23,FYVE,Signal Transduction,G protein signaling,Signal Transduction,FGD5

Molecular Weight: 61kDa/159kDa

Gene ID: 152273

UniProt: Q6ZNL6