HAP1 antibody (AA 1-240)

Catalog No. ABIN7267795

This Rabbit Polyclonal antibody specifically detects HAP1 in WB. It exhibits reactivity toward Human.

Quick Overview for HAP1 antibody (AA 1-240) (ABIN7267795)

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HAP1 Antibody

Binding Specificity: AA 1-240

Purpose: HAP1 Rabbit pAb

Sequence: MRPKRLGRCC AGSRLGPGDP AALTCAPSPS ASPAPEPSAQ PQARGTGQRV GSRATSGSQF LSEARTGARP ASEAGAKAGA RRPSAFSAIQ GDVRSMPDNS DAPWTRFVFQ GPFGSRATGR GTGKAAGIWK TPAAYVGRRP GVSGPERAAF IRELEEALCP NLPPPVKKIT QEDVKVMLYL LEELLPPVWE SVTYGMVLQR ERDLNTAARI GQSLVKQNSV LMEENSKLEA LLGSAKEEIL

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HAP1 (NP_817084.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HAP1

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Alternative Name: HAP1

Background: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.,HAP1;HAP2;HIP5;HLP;hHLP1,Signal Transduction,Neuroscience,Neurodegenerative Diseases,HAP1

Molecular Weight: 66kDa/67kDa/69kDa/75kDa

Gene ID: 9001

UniProt: P54257

Pathways: Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus