IQSEC1 antibody (AA 180-380)

Catalog No. ABIN7268018

The Rabbit Polyclonal anti-IQSEC1 antibody has been validated for WB. It is suitable to detect IQSEC1 in samples from Human.

Quick Overview for IQSEC1 antibody (AA 180-380) (ABIN7268018)

Target: IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IQSEC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IQSEC1 Antibody

Binding Specificity: AA 180-380

Purpose: IQSEC1 Rabbit pAb

Sequence: SFEGPEKVHS SYFEGKQVSV TNDGSQLGAL VSPECGDLSE PTTLKSPAPS SDFADAITEL EDAFSRQVKS LAESIDDALN CRSLHTEEAP ALDAARARDT EPQTALHGMD HRKLDEMTAS YSDVTLYIDE EELSPPLPLS QAGDRPSSTE SDLRLRAGGA APDYWALAHK EDKADTDTSC RSTPSLERQE QRLRVEHLPL L

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_055684.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IQSEC1

Target: IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))

Alternative Name: IQSEC1

Background: Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin. Involved in neuronal development (Probable. In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity.,IQSEC1,ARF-GEP100,ARFGEP100,BRAG2,GEP100,Cancer,Signal Transduction,G protein signaling,Signal Transduction,ErbB-HER Signaling Pathway,IQSEC1

Molecular Weight: 108kDa

Gene ID: 9922

UniProt: Q6DN90