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LRP6 antibody (AA 20-150)

This Rabbit Polyclonal antibody specifically detects LRP6 in IF. It exhibits reactivity toward Human.
Catalog No. ABIN7268299

Quick Overview for LRP6 antibody (AA 20-150) (ABIN7268299)

Target

See all LRP6 Antibodies
LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Reactivity

  • 76
  • 48
  • 24
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 66
  • 10
  • 1
  • 1
Rabbit

Clonality

  • 65
  • 13
Polyclonal

Conjugate

  • 29
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This LRP6 antibody is un-conjugated

Application

  • 61
  • 27
  • 26
  • 25
  • 19
  • 18
  • 12
  • 12
  • 8
  • 6
  • 2
  • 2
  • 1
Immunofluorescence (IF)
  • Binding Specificity

    • 22
    • 22
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 20-150

    Purpose

    LRP6 Rabbit pAb

    Sequence

    APLLLYANRR DLRLVDATNG KENATIVVGG LEDAAAVDFV FSHGLIYWSD VSEEAIKRTE FNKTESVQNV VVSGLLSPDG LACDWLGEKL YWTDSETNRI EVSNLDGSLR KVLFWQELDQ PRAIALDPSS G

    Cross-Reactivity

    Human

    Characteristics

    Polyclonal Antibodies

    Purification

    Affinity purification

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human LRP6 (NP_002327.2).

    Isotype

    IgG
  • Application Notes

    IF,1:50 - 1:200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

    Alternative Name

    LRP6

    Background

    This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.,LRP6,ADCAD2,STHAG7,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Microtubules,Wnt/β-Catenin Signaling Pathway,ESC Pluripotency and Differentiation,Stem Cells,LRP6

    Molecular Weight

    180kDa

    Gene ID

    4040

    UniProt

    O75581

    Pathways

    WNT Signaling, Tube Formation
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