MASP2 antibody (AA 445-686)

Catalog No. ABIN7268387

The Rabbit Polyclonal anti-MASP2 antibody has been validated for WB. It is suitable to detect MASP2 in samples from Human.

Quick Overview for MASP2 antibody (AA 445-686) (ABIN7268387)

Target: MASP2 (Mannan-Binding Lectin serine Peptidase 2 (MASP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MASP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MASP2 Antibody

Binding Specificity: AA 445-686

Purpose: MASP2 Rabbit pAb

Sequence: IYGGQKAKPG DFPWQVLILG GTTAAGALLY DNWVLTAAHA VYEQKHDASA LDIRMGTLKR LSPHYTQAWS EAVFIHEGYT HDAGFDNDIA LIKLNNKVVI NSNITPICLP RKEAESFMRT DDIGTASGWG LTQRGFLARN LMYVDIPIVD HQKCTAAYEK PPYPRGSVTA NMLCAGLESG GKDSCRGDSG GALVFLDSET ERWFVGGIVS WGSMNCGEAG QYGVYTKVIN YIPWIENIIS DF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 445-686 of human MASP2 (NP_006601.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MASP2

Target: MASP2 (Mannan-Binding Lectin serine Peptidase 2 (MASP2))

Alternative Name: MASP2

Background: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.,MASP2,MAP19,MASP-2,MASP1P1,sMAP,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,Cardiovascular,Blood,Serum Proteins,MASP2

Molecular Weight: 20kDa/75kDa

Gene ID: 10747

UniProt: O00187

Pathways: Complement System