PDE11A antibody (AA 712-933)

Catalog No. ABIN7269298

This Rabbit Polyclonal antibody specifically detects PDE11A in WB and IF. It exhibits reactivity toward Human.

Quick Overview for PDE11A antibody (AA 712-933) (ABIN7269298)

Target: PDE11A (phosphodiesterase 11A (PDE11A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE11A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PDE11A Antibody

Binding Specificity: AA 712-933

Purpose: PDE11A Rabbit pAb

Sequence: NNAFQAKSGS ALAQLYGTSA TLEHHHFNHA VMILQSEGHN IFANLSSKEY SDLMQLLKQS ILATDLTLYF ERRTEFFELV SKGEYDWNIK NHRDIFRSML MTACDLGAVT KPWEISRQVA ELVTSEFFEQ GDRERLELKL TPSAIFDRNR KDELPRLQLE WIDSICMPLY QALVKVNVKL KPMLDSVATN RSKWEELHQK RLLASTASSS PASVMVAKED RN

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 712-933 of human PDE11A (NP_058649.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDE11A

Target: PDE11A (phosphodiesterase 11A (PDE11A))

Alternative Name: PDE11A

Background: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.,PDE11A;PPNAD2,PDE11A

Molecular Weight: 55kDa/65kDa/78kDa/104kDa

Gene ID: 50940

UniProt: Q9HCR9

Pathways: cAMP Metabolic Process