PLSCR1 antibody

Catalog No. ABIN7269354

This anti-PLSCR1 antibody is a Rabbit Monoclonal antibody detecting PLSCR1 in WB, IHC and IF. Suitable for Human.

Quick Overview for PLSCR1 antibody (ABIN7269354)

Target: PLSCR1 (phospholipid Scramblase 1 (PLSCR1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PLSCR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PLSCR1 Antibody

Purpose: Phospholipid Scramblase 1 (PLSCR1) Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Phospholipid Phospholipid Scramblase 1 (PLSCR1) (PLSCR1)

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PLSCR1

Target: PLSCR1 (phospholipid Scramblase 1 (PLSCR1))

Alternative Name: PLSCR1

Background: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity. Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A. Negatively regulates FcR-mediated phagocytosis in differentiated macrophages. May contribute to cytokine-regulated cell proliferation and differentiation (By similarity. May play a role in the antiviral response of interferon (IFN by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. Acts as an attachment receptor for HCV.,MMTRA1B,Calcium Signaling,Cardiovascular,Lipids,Lipids_Lipoproteins/Apolipoproteins,Neuroscience,Signal Transduction,PLSCR1

Molecular Weight: 35kDa

Gene ID: 5359

UniProt: O15162

Pathways: Cellular Response to Molecule of Bacterial Origin