PRDM9 antibody

Catalog No. ABIN7269501

Product Details anti-PRDM9 Antibody

Target: PRDM9 (PR Domain Containing 9 (PRDM9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM9 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: PRDM9 Rabbit pAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human PRDM9.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PRDM9

Target: PRDM9 (PR Domain Containing 9 (PRDM9))

Alternative Name: PRDM9 (PRDM9 Products)

Background: The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described.,PFM6, KMT8B, MSBP3, ZNF899, MEISETZ,PRDM9

Molecular Weight: 103kDa

Gene ID: 56979

UniProt: Q9NQV7