PNRC2 antibody (AA 1-100)

Catalog No. ABIN7269556

This Rabbit Polyclonal antibody specifically detects PNRC2 in WB. It exhibits reactivity toward Human.

Quick Overview for PNRC2 antibody (AA 1-100) (ABIN7269556)

Target: PNRC2 (Proline Rich Nuclear Receptor Coactivator 2 (PNRC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNRC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PNRC2 Antibody

Binding Specificity: AA 1-100

Purpose: PNRC2 Rabbit pAb

Sequence: MGGGERYNIP APQSRNVSKN QQQLNRQKTK EQNSQMKIVH KKKERGHGYN SSAAAWQAMQ NGGKNKNFPN NQSWNSSLSG PRLLFKSQAN QNYAGAKFSE

Cross-Reactivity: Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNRC2 (NP_060231.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PNRC2

Target: PNRC2 (Proline Rich Nuclear Receptor Coactivator 2 (PNRC2))

Alternative Name: PNRC2

Background: Involved in nonsense-mediated mRNA decay (NMD by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity.,PNRC2,PNRC2

Molecular Weight: 13kDa/15kDa

Gene ID: 55629

UniProt: Q9NPJ4