PACSIN1 antibody (AA 240-390)

Catalog No. ABIN7269626

The Rabbit Polyclonal anti-PACSIN1 antibody has been validated for WB. It is suitable to detect PACSIN1 in samples from Human.

Quick Overview for PACSIN1 antibody (AA 240-390) (ABIN7269626)

Target: PACSIN1 (Protein Kinase C and Casein Kinase Substrate in Neurons 1 (PACSIN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PACSIN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PACSIN1 Antibody

Binding Specificity: AA 240-390

Purpose: PACSIN1 Rabbit pAb

Sequence: KRLVFLKEVL LDIKRHLNLA ENSSYIHVYR ELEQAIRGAD AQEDLRWFRS TSGPGMPMNW PQFEEWNPDL PHTTTKKEKQ PKKAEGVALT NATGAVESTS QAGDRGSVSS YDRGQPYATE WSDDESGNPF GGSETNGGAN PFEDDSKGVR V

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 240-390 of human PACSIN1 (NP_065855.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PACSIN1

Target: PACSIN1 (Protein Kinase C and Casein Kinase Substrate in Neurons 1 (PACSIN1))

Alternative Name: PACSIN1

Background: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT, this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis, this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity. Binds to membranes via its F-BAR domain and mediates membrane tubulation.,PACSIN1,SDPI,Signal Transduction,PACSIN1

Molecular Weight: 50kDa

Gene ID: 29993

UniProt: Q9BY11