PPP1CA antibody (pThr320)

Catalog No. ABIN7269674

The Rabbit Polyclonal anti-PPP1CA antibody has been validated for WB and IHC. It is suitable to detect PPP1CA in samples from Human.

Quick Overview for PPP1CA antibody (pThr320) (ABIN7269674)

Target: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1CA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PPP1CA Antibody

Binding Specificity: pThr320

Purpose: Phospho-PPP1CA-T320 Rabbit pAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding T320 of human PPP1CA

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PPP1CA

Target: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Alternative Name: PPP1CA

Background: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.,PPP1CA,PP-1A,PP1A,PP1alpha,PPP1A,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Dephosphorylation,Translation Control,Regulation of eIF2,Cancer,Signal Transduction,G protein signaling,Kinase,Serine/threonine kinases,MAPK-Erk Signaling Pathway,Endocrine & Metabolism,Lipid Metabolism,Insulin Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Dopamine Signaling in Parkinson's Disease,Protein phosphorylation,PPP1CA

Molecular Weight: 32kDa/37kDa/38kDa

Gene ID: 5499

UniProt: P62136

Pathways: M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism