RAB3A antibody (AA 100-200)

Catalog No. ABIN7269809

The Rabbit Polyclonal anti-RAB3A antibody has been validated for WB and IF. It is suitable to detect RAB3A in samples from Human.

Quick Overview for RAB3A antibody (AA 100-200) (ABIN7269809)

Target: RAB3A (RAB3A, Member RAS Oncogene Family (RAB3A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB3A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-RAB3A Antibody

Binding Specificity: AA 100-200

Purpose: RAB3A Rabbit pAb

Sequence: LMYDITNEES FNAVQDWSTQ IKTYSWDNAQ VLLVGNKCDM EDERVVSSER GRQLADHLGF EFFEASAKDN INVKQTFERL VDVICEKMSE SLDTADPAVT G

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RAB3A (NP_002857.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RAB3A

Target: RAB3A (RAB3A, Member RAS Oncogene Family (RAB3A))

Alternative Name: RAB3A

Background: Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity. Interacts with MADD (via uDENN domain, the GTP-bound form is preferred for interaction (By similarity.,RAB3A,Signal Transduction,G protein signaling,Signal Transduction,RAB3A

Molecular Weight: 24kDa

Gene ID: 5864

UniProt: P20336

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport