Sema4a antibody (AA 320-580)

Catalog No. ABIN7270199

The Rabbit Polyclonal anti-Sema4a antibody has been validated for WB and IF. It is suitable to detect Sema4a in samples from Human.

Quick Overview for Sema4a antibody (AA 320-580) (ABIN7270199)

Target: Sema4a (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sema4a antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Sema4a Antibody

Binding Specificity: AA 320-580

Purpose: SEMA4A Rabbit pAb

Sequence: IYAVFTSQWQ VGGTRSSAVC AFSLLDIERV FKGKYKELNK ETSRWTTYRG PETNPRPGSC SVGPSSDKAL TFMKDHFLMD EQVVGTPLLV KSGVEYTRLA VETAQGLDGH SHLVMYLGTT TGSLHKAVVS GDSSAHLVEE IQLFPDPEPV RNLQLAPTQG AVFVGFSGGV WRVPRANCSV YESCVDCVLA RDPHCAWDPE SRTCCLLSAP NLNSWKQDME RGNPEWACAS GPMSRSLRPQ SRPQIIKEVL AVPNSILELP C

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 320-580 of human SEMA4A (NP_071762.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Sema4a

Target: Sema4a (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))

Alternative Name: SEMA4A

Background: This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.,SEMA4A,CORD10,RP35,SEMAB,SEMB,Neuroscience,Cardiovascular,Angiogenesis,SEMA4A

Molecular Weight: 69kDa/83kDa

Gene ID: 64218

UniProt: Q9H3S1