TAX1BP3 antibody

Catalog No. ABIN7270742

The Rabbit Monoclonal anti-TAX1BP3 antibody has been validated for WB. It is suitable to detect TAX1BP3 in samples from Human.

Quick Overview for TAX1BP3 antibody (ABIN7270742)

Target: TAX1BP3 (Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 3 (TAX1BP3))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TAX1BP3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TAX1BP3 Antibody

Purpose: TAX1BP3 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human TAX1BP3

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TAX1BP3

Target: TAX1BP3 (Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 3 (TAX1BP3))

Alternative Name: TAX1BP3

Background: This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways, for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,TIP-1, TIP1,Epigenetics & Nuclear Signaling,G protein signaling,G protein signaling_Small G proteins,Signal Transduction,Stem Cells,TAX1BP3

Molecular Weight: 14kDa

Gene ID: 30851

UniProt: O14907

Pathways: Monocarboxylic Acid Catabolic Process