TBC1D5 antibody (AA 446-795)

Catalog No. ABIN7270750

This Rabbit Polyclonal antibody specifically detects TBC1D5 in WB. It exhibits reactivity toward Human.

Quick Overview for TBC1D5 antibody (AA 446-795) (ABIN7270750)

Target: TBC1D5 (TBC1 Domain Family, Member 5 (TBC1D5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TBC1D5 Antibody

Binding Specificity: AA 446-795

Purpose: TBC1D5 Rabbit pAb

Sequence: NAKGAPLNIN KVSNSLINFG RKLISPAMAP GSAGGPVPGG NSSSSSSVVI PTRTSAEAPS HHLQQQQQQQ RLMKSESMPV QLNKGLSSKN ISSSPSVESL PGGREFTGSP PSSATKKDSF FSNISRSRSH SKTMGRKESE EELEAQISFL QGQLNDLDAM CKYCAKVMDT HLVNIQDVIL QENLEKEDQI LVSLAGLKQI KDILKGSLRF NQSQLEAEEN EQITIADNHY CSSGQGQGRG QGQSVQMSGA IKQASSETPG CTDRGNSDDF ILISKDDDGS SARGSFSGQA QPLRTLRSTS GKSQAPVCSP LVFSDPLMGP ASASSSNPSS SPDDDSSKDS GFTIVSPLDI

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 446-795 of human TBC1D5 (NP_055559.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TBC1D5

Target: TBC1D5 (TBC1 Domain Family, Member 5 (TBC1D5))

Alternative Name: TBC1D5

Background: May act as a GTPase-activating protein (GAP for Rab family protein(s. May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol, at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN, the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes.,TBC1D5,TBC1D5

Molecular Weight: 89kDa/91kDa

Gene ID: 9779

UniProt: Q92609