TGFB2 antibody (AA 20-160)

Catalog No. ABIN7270911

This anti-TGFB2 antibody is a Rabbit Polyclonal antibody detecting TGFB2 in WB and IHC. Suitable for Human.

Quick Overview for TGFB2 antibody (AA 20-160) (ABIN7270911)

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TGFB2 Antibody

Binding Specificity: AA 20-160

Purpose: TGFB2 Rabbit pAb

Sequence: SLSTCSTLDM DQFMRKRIEA IRGQILSKLK LTSPPEDYPE PEEVPPEVIS IYNSTRDLLQ EKASRRAAAC ERERSDEEYY AKEVYKIDMP PFFPSETVCP VVTTPSGSVG SLCSRQSQVL CGYLDAIPPT FYRPYFRIVR F

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human TGFB2 (NP_001129071.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TGFB2

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Alternative Name: TGFB2

Background: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1,7)(q41,p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.,TGFB2,G-TSF,LDS4,TGF-beta2,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Growth factor,TGF-b-Smad Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Endocrine & Metabolism,Stem Cells,Cardiovascular,Angiogenesis,Angiogenic growth factors,Ligand,TGFB2

Molecular Weight: 47kDa/50kDa

Gene ID: 7042

UniProt: P61812

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus