TMED10 antibody (AA 35-190)

Catalog No. ABIN7270945

This Rabbit Polyclonal antibody specifically detects TMED10 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for TMED10 antibody (AA 35-190) (ABIN7270945)

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMED10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Grade: KO Validated

Product Details anti-TMED10 Antibody

Binding Specificity: AA 35-190

Purpose: [KO Validated] TMED10 Rabbit pAb

Sequence: HLPINSRKCL REEIHKDLLV TGAYEISDQS GGAGGLRSHL KITDSAGHIL YSKEDATKGK FAFTTEDYDM FEVCFESKGT GRIPDQLVIL DMKHGVEAKN YEEIAKVEKL KPLEVELRRL EDLSESIVND FAYMKKREEE MRDTNESTNT RVLYFS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 35-190 of human TMED10 (NP_006818.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TMED10

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Alternative Name: TMED10

Background: This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.,TMED10,P24(DELTA),S31I125,S31III125,TMP21,Tmp-21-I,p23,p24d1,Signal Transduction,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,TMED10

Molecular Weight: 24kDa

Gene ID: 10972

UniProt: P49755