TPSB2 antibody (AA 1-275)

Catalog No. ABIN7271018

The Rabbit Polyclonal anti-TPSB2 antibody has been validated for WB. It is suitable to detect TPSB2 in samples from Human.

Quick Overview for TPSB2 antibody (AA 1-275) (ABIN7271018)

Target: TPSB2 (Tryptase beta 2 (TPSB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPSB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TPSB2 Antibody

Binding Specificity: AA 1-275

Purpose: Mast Cell Tryptase (TPSB2) Rabbit pAb

Sequence: MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV RDRYWMHFCG GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human Mast Cell Tryptase (Mast Cell Tryptase (TPSB2)) (NP_077078.5).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TPSB2

Target: TPSB2 (Tryptase beta 2 (TPSB2))

Alternative Name: TPSB2

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.,TPSB2,TPS2,tryptaseB,tryptaseC,Cell Biology & Developmental Biology,Ubiquitin,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,TPSB2

Molecular Weight: 30kDa

Gene ID: 64499

UniProt: P20231