Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex, interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.,TBCE,HRD,KCS,KCS1,PEAMO,pac2,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microtubules,Growth factor,Neuroscience,Neurodegenerative Diseases,TBCE