UBQLN4 antibody (AA 300-390)

Catalog No. ABIN7271124

This anti-UBQLN4 antibody is a Rabbit Polyclonal antibody detecting UBQLN4 in WB, IHC and IF. Suitable for Human.

Quick Overview for UBQLN4 antibody (AA 300-390) (ABIN7271124)

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBQLN4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-UBQLN4 Antibody

Binding Specificity: AA 300-390

Purpose: UBQLN4 Rabbit pAb

Sequence: QFGNNPFSSL AGNSDSSSSQ PLRTENREPL PNPWSPSPPT SQAPGSGGEG TGGSGTSQVH PTVSNPFGIN AASLGSGMFN SPEMQALLQQ I

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-390 of human UBQLN4 (NP_064516.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Alternative Name: UBQLN4

Background: Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ. Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation. Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity. Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.,UBQLN4,A1U,A1Up,C1orf6,CIP75,UBIN,Cell Biology & Developmental Biology,Ubiquitin,UBQLN4

Molecular Weight: 24kDa/63kDa

Gene ID: 56893

UniProt: Q9NRR5