APC antibody (AA 1-50)

Catalog No. ABIN7448412

This anti-APC antibody is a Rabbit Polyclonal antibody detecting APC in IHC. Suitable for Human.

Quick Overview for APC antibody (AA 1-50) (ABIN7448412)

Target: APC (Adenomatous Polyposis Coli (APC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-APC Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-APC IHC Antibody, affinity purified

Predicted Reactivity: Mouse,Rat,Zebrafish,X. tropicalis,Chicken,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Monkey,Gorilla,Chimpanzee,Duckbill platypus,Crab-eating macaque,African elephant,Little brown bat,Zebra finch,Small-eared galago,Gray short-tailed opossum,White-tufted-ear marmoset,Tasmanian devil,Northern white-cheeked gibbon,Naked mole rat

Purification: Affinity Purified

Immunogen: Between AA 1 and 50

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for APC

Target: APC (Adenomatous Polyposis Coli (APC))

Alternative Name: APC

Background: Background: Adenomatosis polyposis coli (APC) is a tumor suppressor gene found to be mutated in most colon cancers and is the cause of familial adenomatous polyposis (FAP), an autosomal dominant disease that results in a predisposition to malignant colon cancer. APC has been shown to be involved in cell differentiation, migration, proliferation and adhesion. One function of APC involves its role as a scaffolding protein that regulates the phosphorylation and degradation of beta-catenin, a transcriptional regulator in the WNT signaling pathway. Additionally, APC has been found to be important in the regulation of microtubule arrays and mitotic spindle formation.

Gene ID: 324

NCBI Accession: NP_000029

UniProt: P25054

Pathways: WNT Signaling, Stem Cell Maintenance, Cell-Cell Junction Organization