XPO1 antibody (C-Term)

Catalog No. ABIN7448488

This Rabbit Polyclonal antibody specifically detects XPO1 in IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for XPO1 antibody (C-Term) (ABIN7448488)

Target: XPO1 (Exportin 1 (XPO1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPO1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-XPO1 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-CRM1 IHC Antibody, Affinity Purified

Predicted Reactivity: Orangutan,Monkey,Gorilla,Chimpanzee,Northern white-cheeked gibbon,Crab-eating macaque,White-tufted-ear marmoset

Purification: Affinity Purified

Immunogen: Between AA 1025 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for XPO1

Target: XPO1 (Exportin 1 (XPO1))

Alternative Name: CRM1

Background: Background: Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.

Gene ID: 7514

NCBI Accession: NP_003391

UniProt: O14980

Pathways: M Phase