CSN3 antibody (AA 325-375)

Catalog No. ABIN7448493

This anti-CSN3 antibody is a Rabbit Polyclonal antibody detecting CSN3 in IHC. Suitable for Human.

Quick Overview for CSN3 antibody (AA 325-375) (ABIN7448493)

Target: CSN3 (Casein kappa (CSN3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSN3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-CSN3 Antibody

Binding Specificity: AA 325-375

Purpose: Rabbit anti-CSN3 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,X. tropicalis,Chicken,Turkey,Bovine,Dog,Horse,Guinea pig_10141,Panda,Orangutan,Monkey,Chimpanzee,White-tufted-ear marmoset,Crab-eating macaque,Tasmanian devil,African elephant,Green anole,Small-eared galago,Gray short-tailed opossum,Naked mole rat,Chinese hamster,Thirteen-lined ground squirrel,Duckbill platypus,West Indian ocean coelacanth,Little brown bat,Zebra finch,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 325 and 375

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CSN3

Target: CSN3 (Casein kappa (CSN3))

Alternative Name: CSN3

Background: Background: CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.

Gene ID: 8533

NCBI Accession: NP_003644

UniProt: Q9UNS2