DDX3X antibody (AA 1-50)

Catalog No. ABIN7448520

This anti-DDX3X antibody is a Rabbit Polyclonal antibody detecting DDX3X in IHC. Suitable for Human and Mouse.

Quick Overview for DDX3X antibody (AA 1-50) (ABIN7448520)

Target: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDX3X antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DDX3X Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-DDX3 IHC Antibody, Affinity Purified

Predicted Reactivity: Rat,Bovine,Dog,Rabbit,Pig,Golden hamster,Panda,Orangutan,Monkey,Gorilla,Crab-eating macaque,Naked mole rat,African elephant,Chinese hamster,White-tufted-ear marmoset,Common vole,Little brown bat,Small-eared galago,Hystricognathi,Southern vole,Tasmanian devil,Green anole,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 1 and 50

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for DDX3X

Target: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Alternative Name: DDX3

Background: Background: DDX3 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX3 exhibits a variety of functions. DDX3 is a candidate tumor suppressor that suppresses tumor growth and transcriptionally activates the p21 promoter. DDX3 has been shown to play a role in translation as an eIF4E inhibitory protein that regulates translation initiation. These findings, as well as the observation that DDX3 is regulated by hepatitis C virus and is down-regulated in hepatocellular carcinoma, suggest an important role for DDX3 in growth-regulatory functions.

Gene ID: 1654

NCBI Accession: NP_001347

UniProt: O00571

Pathways: Ribonucleoprotein Complex Subunit Organization, Positive Regulation of Endopeptidase Activity, Negative Regulation of intrinsic apoptotic Signaling, Ribosome Assembly