PUS1 antibody (AA 377-427)

Catalog No. ABIN7448747

The Rabbit Polyclonal anti-PUS1 antibody has been validated for IHC. It is suitable to detect PUS1 in samples from Human.

Quick Overview for PUS1 antibody (AA 377-427) (ABIN7448747)

Target: PUS1 (Pseudouridylate Synthase 1 (PUS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PUS1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PUS1 Antibody

Binding Specificity: AA 377-427

Purpose: Rabbit anti-PUS1 IHC Antibody, Affinity Purified

Predicted Reactivity: Orangutan,Gorilla,Chimpanzee,White-tufted-ear marmoset,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 377 and 427

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PUS1

Target: PUS1 (Pseudouridylate Synthase 1 (PUS1))

Alternative Name: PUS1

Background: Background: Pus1 (pseudouridylate synthase 1) is an enzyme that converts uridine to pseudouridine in non-coding RNA substrates. Pus1 modifies uridines at specific positions in a subset of tRNAs. Pseudouridylation is known to affect the structure of tRNAs and stabilize base-stacking and base-pairing in the anticodon loop. Pus1 activity is important for proper folding and function of tRNAs. Pus1 has also been shown to pseudouridylate SRA (steroid receptor RNA activator) and function as a coactivator. Defects in pseudouridylation are associated with the human disease, MLASA (myopathy with lactic acidosis and sideroblastic anemia), an autosomal recessive oxidative phosphorylataion disorder specific to skeletal muscle and bone marrow.

Gene ID: 80324

NCBI Accession: NP_079491

UniProt: Q9Y606