USP1 antibody (AA 450-500)

Catalog No. ABIN7448850

This anti-USP1 antibody is a Rabbit Polyclonal antibody detecting USP1 in IHC. Suitable for Human.

Quick Overview for USP1 antibody (AA 450-500) (ABIN7448850)

Target: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-USP1 Antibody

Binding Specificity: AA 450-500

Purpose: Rabbit anti-USP1 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Chicken,Turkey,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,African elephant,Zebra finch,Ferret,Northern white-cheeked gibbon,Crab-eating macaque,Thirteen-lined ground squirrel,Little brown bat,Naked mole rat,Small-eared galago,White-tufted-ear marmoset

Purification: Affinity Purified

Immunogen: Between AA 450 and 500

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for USP1

Target: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Alternative Name: USP1

Background: Background: Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 1 (USP1) has been found to play a role in the Fanconi anemia DNA repair pathway. USP1 specifically removes monoubiquitination from the Fanconi anemia D2 (FANCD2) protein and from the proliferating cell nuclear antigen (PCNA). Deubiquitination of FANCD2 and PCNA is critical to their role in the DNA damage response and DNA crosslink repair.

Gene ID: 7398

NCBI Accession: NP_003359

UniProt: O94782