UBR4 antibody (AA 5133-5183)

Catalog No. ABIN7448995

This Rabbit Polyclonal antibody specifically detects UBR4 in IHC and IF (p). It exhibits reactivity toward Human.

Quick Overview for UBR4 antibody (AA 5133-5183) (ABIN7448995)

Target: UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-UBR4 Antibody

Binding Specificity: AA 5133-5183

Purpose: Rabbit anti-p600 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Horse,Pig,Orangutan,Monkey,Gorilla,Chimpanzee,Little brown bat,Northern white-cheeked gibbon,White-tufted-ear marmoset

Purification: Affinity Purified

Immunogen: Between AA 5133 and 5183

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for UBR4

Target: UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))

Alternative Name: p600

Background: Background: p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions [taken from the Universal Protein Resource (UniProt) Q5T4S7].

Gene ID: 23352

NCBI Accession: NP_065816

UniProt: Q5T4S7