DIS3L2 antibody (AA 475-525)

Catalog No. ABIN7449190

This Rabbit Polyclonal antibody specifically detects DIS3L2 in WB. It exhibits reactivity toward Human.

Quick Overview for DIS3L2 antibody (AA 475-525) (ABIN7449190)

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIS3L2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DIS3L2 Antibody

Binding Specificity: AA 475-525

Purpose: Rabbit anti-DIS3L2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 475 and 525

Isotype: IgG

Application Details

Application Notes: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for DIS3L2

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Alternative Name: DIS3L2

Background: Background: DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) Q8IYB7].

Gene ID: 129563

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance