APOA1 antibody (HRP)

Catalog No. ABIN7449327

This anti-APOA1 antibody is a Goat Polyclonal antibody detecting APOA1 in WB and ELISA. Suitable for Human.

Quick Overview for APOA1 antibody (HRP) (ABIN7449327)

Target: APOA1 (Apolipoprotein A-I (APOA1))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This APOA1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA

Clone: H03

Product Details anti-APOA1 Antibody (HRP)

Purpose: Goat anti-Human Apo AI [H03] Antibody HRP Conjugated

Immunogen: Human Apolipoprotein AI

Isotype: IgG

Application Details

Application Notes:

WB: 1:1,000 - 1:8,000

ELISA: 1:1,000 - 1:8,000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 50 mM PBS, 0.1 M NaCl, and 0.01 % Thiomersal, pH 7.4

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for APOA1

Target: APOA1 (Apolipoprotein A-I (APOA1))

Alternative Name: ApoAI

Background: Background: Apo AI comprises approximately 70 % of the protein moiety in HDL. It is a single polypeptide chain consisting of 243 amino acid residues without disulfide bound and with glutamic acid as the C-terminal residue and aspartic acid as the N-terminal residue. The molecular weight is reported to be 28 kDa (Brewer et al., 1978). The roles of Apo AI in HDL function include reverse cholesterol transportation, lipid cholesterol binding, lecithin-cholesterol acyl transferase (LCAT) activation, and receptor binding, which is responsible for cholesterol esterification in plasma. Besides participate in cholesterol metabolism, Apo AI and HDL also suppress neutrophil activation, inhibit bacterial endotoxin, induce trypanosomal lysis, and other physiological activities. (Brouillette et al., 2001). Apo AI levels may be inversely related to the risk of coronary disease. In previous research, Apo AI may affect diet-induced inflammation by either directly or indirectly altering lipid rafts. (Cheng et al., 2012)

Gene ID: 335

NCBI Accession: NP_000030

UniProt: P02647

Pathways: Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism