Recombinant CD16 antibody (AA 21-201)

Catalog No. ABIN7449423

This anti-CD16 antibody is a Rabbit Monoclonal antibody detecting CD16 in WB, IHC and ICC. Suitable for Human.

Quick Overview for Recombinant CD16 antibody (AA 21-201) (ABIN7449423)

Target: CD16

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD16 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: BLR163J

Product Details anti-CD16 Antibody

Binding Specificity: AA 21-201

Purpose: Rabbit anti-CD16 Recombinant Monoclonal Antibody [BLR163J]

Immunogen: residues 21-201 (ECD)

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CD16

Target: CD16

Alternative Name: CD16

Background: Background: CD16A (FCGR3A) is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. CD16A is highly similar to another nearby gene (CD16B, FCGR3B) located on chromosome 1. CD16A is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas CD16B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. [taken from NCBI Entrez Gene (Gene ID: 2214)].

Gene ID: 2214, 2215

NCBI Accession: NP_000560

UniProt: P08637, O75015

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process