HRPT2 antibody (AA 250-300)

Catalog No. ABIN7449603

This anti-HRPT2 antibody is a Rabbit Polyclonal antibody detecting HRPT2 in WB and IP. Suitable for Human and Mouse.

Quick Overview for HRPT2 antibody (AA 250-300) (ABIN7449603)

Target: HRPT2 (CDC73) (Parafibromin (CDC73))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRPT2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-HRPT2 Antibody

Binding Specificity: AA 250-300

Purpose: Rabbit anti-Parafibromin Antibody, Affinity Purified

Predicted Reactivity: Rat

Purification: Affinity Purified

Immunogen: between AA 250 and 300

Isotype: IgG

Application Details

Application Notes:

IP: 1 - 4 μg/mg lysate

WB: 1:5,000 - 1:20,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for HRPT2

Target: HRPT2 (CDC73) (Parafibromin (CDC73))

Alternative Name: Parafibromin

Background: Background: Parafibromin, also known as HRPT2 (hyperparathyroidism 2 protein), has been identified as a tumor suppressor that is associated with hyperparathyroidism-jaw tumor syndrome, an autosomal dominant disease characterized by hyperparathyroidism due to parathyroid tumors and ossifying fibromas of the mandible and maxilla. Parafibromin is a component of the PAF1 complex that associates with RNA polymerase II and plays a role in mRNA 3'-end processing and transcription elongation. Parafibromin has been demonstrated to function as an inhibitor of the cell cycle.

Gene ID: 79577

NCBI Accession: NP_078805

UniProt: Q6P1J9

Pathways: Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance