Ataxin 1 antibody (AA 350-400)

Catalog No. ABIN7449649

This Rabbit Polyclonal antibody specifically detects Ataxin 1 in IP. It exhibits reactivity toward Human.

Quick Overview for Ataxin 1 antibody (AA 350-400) (ABIN7449649)

Target: Ataxin 1 (ATXN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 1 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-Ataxin 1 Antibody

Binding Specificity: AA 350-400

Purpose: Rabbit anti-Ataxin-1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 350 and 400

Isotype: IgG

Application Details

Application Notes:

IP: 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-Ataxin-1 antibody A302-292A.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Ataxin 1

Target: Ataxin 1 (ATXN1)

Alternative Name: Ataxin-1

Background: Background: Defects in ataxin-1 are the cause of spinocerebellar ataxia type 1 (SCA1), also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 is caused by expansion of a CAG repeat in the coding region of the ataxin-1 gene. Longer expansions result in earlier onset and more severe clinical manifestations of the disease. Ataxin-1 binds RNA in vitro and may be involved in RNA metabolism [taken from the Universal Protein Resource (UniProt) P54253].

Gene ID: 6310

NCBI Accession: NP_000323

UniProt: P54253

Pathways: Synaptic Membrane