CD2AP antibody (AA 689-639)

Catalog No. ABIN7450093

This Rabbit Polyclonal antibody specifically detects CD2AP in WB and IP. It exhibits reactivity toward Human.

Quick Overview for CD2AP antibody (AA 689-639) (ABIN7450093)

Target: CD2AP (Cd2ap) (CD2-Associated Protein (Cd2ap))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD2AP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-CD2AP Antibody

Binding Specificity: AA 689-639

Purpose: Rabbit anti-CD2AP Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 689 and 639

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CD2AP

Target: CD2AP (Cd2ap) (CD2-Associated Protein (Cd2ap))

Alternative Name: CD2AP

Background: Background: CD2-associated protein (CD2AP) seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, it modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. It also controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. CD2AP may play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell and may anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. CD2AP is also required for cytokinesis [taken from the Universal Protein Resource (UniProt) Q9Y5K6].

Gene ID: 23607

NCBI Accession: NP_036252

UniProt: Q9Y5K6