FERMT2 antibody (AA 175-225)

Catalog No. ABIN7450396

This Rabbit Polyclonal antibody specifically detects FERMT2 in WB and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for FERMT2 antibody (AA 175-225) (ABIN7450396)

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FERMT2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-FERMT2 Antibody

Binding Specificity: AA 175-225

Purpose: Rabbit anti-Kindlin-2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 175 and 225

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for FERMT2

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Alternative Name: Kindlin-2

Background: Background: Kindlin-2 is a scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. It binds to membranes enriched in phosphoinositides. It also enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Kindlin-2 is required for the assembly of focal adhesions and participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Kindlin-2 recruits FBLIM1 to focal adhesions. It plays a role in the TGFB1 and integrin signaling pathways, and it stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling [taken from the Universal Protein Resource (UniProt) Q96AC1].

Gene ID: 10979

NCBI Accession: NP_006823

UniProt: Q96AC1

Pathways: Cell-Cell Junction Organization