Septin 2 antibody (AA 311-361)

Catalog No. ABIN7450721

The Rabbit Polyclonal anti-Septin 2 antibody has been validated for WB and IP. It is suitable to detect Septin 2 in samples from Human and Mouse.

Quick Overview for Septin 2 antibody (AA 311-361) (ABIN7450721)

Target: Septin 2 (SEPT2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Septin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Septin 2 Antibody

Binding Specificity: AA 311-361

Purpose: Rabbit anti-Septin 2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 311 and 361

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Septin 2

Target: Septin 2 (SEPT2)

Alternative Name: Septin 2

Background: Background: Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements [taken from the Universal Protein Resource (UniProt) Q15019].

Gene ID: 4735

NCBI Accession: NP_001008491

UniProt: Q15019