UFD1L antibody (AA 175-225)

Catalog No. ABIN7452139

This Rabbit Polyclonal antibody specifically detects UFD1L in WB and IP. It exhibits reactivity toward Human.

Quick Overview for UFD1L antibody (AA 175-225) (ABIN7452139)

Target: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UFD1L antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-UFD1L Antibody

Binding Specificity: AA 175-225

Purpose: Rabbit anti-UFD1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 175 and 225

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for UFD1L

Target: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Alternative Name: UFD1

Background: Background: Ubiquitin fusion degradation protein 1 homolog (UFD1) forms a dimer with Npl4 (nuclear protein localization 4) and can associate with the ATPase, p97/VCP, to form a ternary complex involved in the ubiquitin-proteasome pathway. The UFD1-p97-Npl4 complex functions to recognize ubiquitin-tagged proteins and facilitate their presentation to the 26S proteasome for degradation. This ternary complex has also been shown to play an important role in mitotic spindle disassembly. Hemizygosity in the gene which encodes UFD1 (UFD1L) is the cause of some catch 22-associated developmental defects. Additionally, the UFD1L gene has also been implicated in the neurodevelopment al origin of schizophrenia.

Gene ID: 7353

NCBI Accession: NP_005650

UniProt: Q92890