Acetyl-CoA Carboxylase alpha antibody (AA 1925-1975)

Catalog No. ABIN7452256

This Rabbit Polyclonal antibody specifically detects Acetyl-CoA Carboxylase alpha in IP. It exhibits reactivity toward Human.

Quick Overview for Acetyl-CoA Carboxylase alpha antibody (AA 1925-1975) (ABIN7452256)

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetyl-CoA Carboxylase alpha antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-Acetyl-CoA Carboxylase alpha Antibody

Binding Specificity: AA 1925-1975

Purpose: Rabbit anti-ACC1/ACC-alpha Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat

Purification: Affinity Purified

Immunogen: between AA 1925 and 1975

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-ACC1/ACC-alpha antibody ABIN7452869.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Acetyl-CoA Carboxylase alpha

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Alternative Name: ACC1/ACC-alpha

Background: Background: ACC1/ACC-alpha catalyzes the carboxylation of acetyl-CoA to malonyl-CoA in the enzymatic pathway of long-chain fatty-acid synthesis. ACC1/ACC-alpha has been identified as a partner of BRCA1. Through this interaction, ACC1/ACC-alpha may contribute to the tumor suppressor activity of BRCA1 as demonstrated by the finding that disruption of this interaction increases lipid synthesis in mammary epithelial cells. In this context, lipogenesis has been closely linked to tumorigenesis and ACC1/ACC-alpha has been found to be highly expressed in human breast carcinomas.

Gene ID: 31

NCBI Accession: NP_942131

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect