FKBP5 antibody (AA 225-275)

Catalog No. ABIN7452330

This anti-FKBP5 antibody is a Rabbit Polyclonal antibody detecting FKBP5 in IP. Suitable for Human.

Quick Overview for FKBP5 antibody (AA 225-275) (ABIN7452330)

Target: FKBP5 (FK506 Binding Protein 5 (FKBP5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP5 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-FKBP5 Antibody

Binding Specificity: AA 225-275

Purpose: Rabbit anti-FKBP5/FKBP51 Antibody, Affinity Purified

Predicted Reactivity: Orangutan

Purification: Affinity Purified

Immunogen: between AA 225 and 275

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-FKBP5/FKBP51 antibody A301-430A.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for FKBP5

Target: FKBP5 (FK506 Binding Protein 5 (FKBP5))

Alternative Name: FKBP5/FKBP51

Background: Background: FKBP5/FKBP51 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP5/FKBP51 exhibits peptidyl-prolyl cis-trans isomerase activity. The most studied role of FKBP5/FKBP51 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperones Hsp90 and Hsp70, FKBP5/FKBP51 is able to influence steroid-hormone binding affinity and transcriptional activity. Recently, FKBP5/FKBP51 has become of interest in the field of psychiatry due to its potential role in cortisol regulation and its relation to mood disorders.

Gene ID: 2289

NCBI Accession: NP_004108

UniProt: Q13451