Recombinant TIM3 antibody (AA 231-281)

Catalog No. ABIN7452586

This Rabbit Monoclonal antibody specifically detects TIM3 in WB and IP. It exhibits reactivity toward Mouse.

Quick Overview for Recombinant TIM3 antibody (AA 231-281) (ABIN7452586)

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TIM3 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: BLR207K

Product Details anti-TIM3 Antibody

Binding Specificity: AA 231-281

Purpose: Rabbit anti-TIM3 Recombinant Monoclonal Antibody [BLR207K]

Purification: Purified

Immunogen: between AA 231 and 281 (C-term)

Isotype: IgG

Application Details

Application Notes:

IP: 20 μL/1 mg lysate

WB: 01:01,00

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details for TIM3

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Alternative Name: TIM3

Target Type: Virus

Background: TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TDQ0].

Gene ID: 171285

UniProt: Q8VIM0

Pathways: Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints