Recombinant TIM3 antibody (AA 231-281)
Quick Overview for Recombinant TIM3 antibody (AA 231-281) (ABIN7452586)
Target
See all TIM3 (TIM 3) AntibodiesAntibody Type
Reactivity
Host
Clonality
Conjugate
Application
Clone
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Binding Specificity
- AA 231-281
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Purpose
- Rabbit anti-TIM3 Recombinant Monoclonal Antibody [BLR207K]
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Immunogen
- between AA 231 and 281 (C-term)
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Isotype
- IgG
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Application Notes
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IP: 20 μL/1 mg lysate
WB: 01:01,00
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Restrictions
- For Research Use only
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Concentration
- 100 μg/mL
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Buffer
- Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Expiry Date
- 12 months
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- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
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Alternative Name
- TIM3
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Target Type
- Virus
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Background
- Background: TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. [taken from the Universal Protein Resource (UniProt) Q8TDQ0].
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Gene ID
- 171285
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NCBI Accession
- NP_599011
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UniProt
- Q8VIM0
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Pathways
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
Target
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