KIAA1524 antibody (N-Term)

Catalog No. ABIN7452647

The Mouse Monoclonal anti-KIAA1524 antibody has been validated for WB and IP. It is suitable to detect KIAA1524 in samples from Human and Mouse.

Quick Overview for KIAA1524 antibody (N-Term) (ABIN7452647)

Target: KIAA1524

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This KIAA1524 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 2A1-9A4

Product Details anti-KIAA1524 Antibody

Binding Specificity: N-Term

Purpose: Mouse anti-CIP2A Monoclonal Antibody, Affinity Purified [2A1-9A4]

Purification: Affinity Purified

Immunogen: Amino terminal one-third of the CIP2A (GeneID 57650) recombinant protein

Isotype: IgG

Application Details

Application Notes:

IP: 20 μL/mg lysate

WB: 17:40:00

Restrictions: For Research Use only

Handling

Concentration: 40 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for KIAA1524

Target: KIAA1524

Alternative Name: CIP2A

Background: Background: CIP2A (cancerous inhibitor of PP2A) was originally identified as p90, a cytoplasmic autoantigen found in the serum from a cancer patient. It was later described as a protein that interacted with the c-myc oncogene and functioned as an inhibitor of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A phosphatase activity by CIP2A prevents c-myc phosphorylation and counteracts c-myc proteolytic degradation, thereby stabilizing c-myc and promoting cell growth and transformation. CIP2A is found to be overexpressed in some human malignancies and is thus classified as an oncogene that may be an important contributor to tumor formation.

Gene ID: 57650

NCBI Accession: NP_065941

UniProt: Q8TCG1