P4HB antibody (AA 50-100)

Catalog No. ABIN7453155

This anti-P4HB antibody is a Rabbit Polyclonal antibody detecting P4HB in WB. Suitable for Human and Mouse.

Quick Overview for P4HB antibody (AA 50-100) (ABIN7453155)

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P4HB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-P4HB Antibody

Binding Specificity: AA 50-100

Purpose: Rabbit anti-P4HB/PDI Antibody, Affinity Purified

Predicted Reactivity: Rat,Bovine,Orangutan

Purification: Affinity Purified

Immunogen: Between AA 50 and 100

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for P4HB

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Alternative Name: P4HB/PDI

Background: Background: P4HB is a multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, P4HB seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity) [taken from the Universal Protein Resource (UniProt) P07237].

Gene ID: 5034

NCBI Accession: NP_000909

UniProt: P07237

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism