SUPT16H antibody (AA 997-1047)

Catalog No. ABIN7453210

This Rabbit Polyclonal antibody specifically detects SUPT16H in WB. It exhibits reactivity toward Human.

Quick Overview for SUPT16H antibody (AA 997-1047) (ABIN7453210)

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUPT16H antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SUPT16H Antibody

Binding Specificity: AA 997-1047

Purpose: Rabbit anti-Spt16 Antibody, Affinity Purified

Predicted Reactivity: Mouse

Purification: Affinity Purified

Immunogen: between AA 997 and 1047

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SUPT16H

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Alternative Name: Spt16

Background: Background: Spt16 is a Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is composed of two subunits: SSRP1 and Spt16. It is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, and then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II [taken from the Universal Protein Resource (UniProt) Q9Y5B9].

Gene ID: 11198

NCBI Accession: NP_009123

UniProt: Q9Y5B9

Pathways: Chromatin Binding