SRPK1 antibody (AA 275-325)

Catalog No. ABIN7453793

The Rabbit Polyclonal anti-SRPK1 antibody has been validated for WB, IP and IHC (fp). It is suitable to detect SRPK1 in samples from Human and Mouse.

Quick Overview for SRPK1 antibody (AA 275-325) (ABIN7453793)

Target: SRPK1 (SRSF Protein Kinase 1 (SRPK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRPK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-SRPK1 Antibody

Binding Specificity: AA 275-325

Purpose: Rabbit anti-SRPK1 Antibody, Affinity Purified

Predicted Reactivity: Orangutan

Purification: Affinity Purified

Immunogen: between AA 275 and 325

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SRPK1

Target: SRPK1 (SRSF Protein Kinase 1 (SRPK1))

Alternative Name: SRPK1

Background: Background: Serine/arginine rich protein-specific kinase 1 (SRPK1) plays a central role in the regulatory network for splicing by controlling the intranuclear distribution of splicing factors in interphase cells and the re-organization of nuclear speckles during mitosis. During metaphase, SRPK1 hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues. SRPK1 also appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids [taken from the Universal Protein Resource (UniProt) Q96SB4].

Gene ID: 6732

NCBI Accession: NP_003128

UniProt: Q96SB4

Pathways: Toll-Like Receptors Cascades