VAPB antibody (AA 100-150)

Catalog No. ABIN7453809

The Rabbit Polyclonal anti-VAPB antibody (ABIN7453809) specifically detects VAPB in WB, IP and IHC (fp). The antibody is reactive with Human and Mouse samples.

Quick Overview for VAPB antibody (AA 100-150) (ABIN7453809)

Target: VAPB (VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAPB antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-VAPB Antibody

Binding Specificity: AA 100-150

Purpose: Rabbit anti-VAPB Antibody, Affinity Purified

Predicted Reactivity: Bovine,Pig

Purification: Affinity Purified

Immunogen: between AA 100 and 150

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for VAPB

Target: VAPB (VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB))

Alternative Name: VAPB

Background: Background: Vesicle-associated membrane protein-associated protein B/C (VAPB) is a type IV membrane protein found in plasma and intracellular vesicle membranes and may play a role in vesicle trafficking. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8. ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Defects in VAPB are also a cause of spinal muscular atrophy autosomal dominant Finkel type (SMAF), also called late-onset spinal muscular atrophy Finkel type or spinal muscular atrophy proximal adult autosomal dominant [taken from the Universal Protein Resource (UniProt) O95292].

Gene ID: 9217

NCBI Accession: NP_004729

UniProt: O95292

Pathways: ER-Nucleus Signaling