OSR1 antibody (AA 325-375)

Catalog No. ABIN7454414

This anti-OSR1 antibody is a Rabbit Polyclonal antibody detecting OSR1 in IP and IHC (fp). Suitable for Human.

Quick Overview for OSR1 antibody (AA 325-375) (ABIN7454414)

Target: OSR1 (Odd-Skipped Related 1 (OSR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OSR1 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-OSR1 Antibody

Binding Specificity: AA 325-375

Purpose: Rabbit anti-OSR1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 325 and 375

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-OSR1 antibody A301-579A.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for OSR1

Target: OSR1 (Odd-Skipped Related 1 (OSR1))

Alternative Name: OSR1

Background: Background: Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.

Gene ID: 9943

NCBI Accession: NP_005100

UniProt: O95747

Pathways: Tube Formation