CDK11 antibody (C-Term)

Catalog No. ABIN7454610

This Rabbit Polyclonal antibody specifically detects CDK11 in WB, IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for CDK11 antibody (C-Term) (ABIN7454610)

Target: CDK11 (CDK11B) (Cyclin-Dependent Kinase 11B (CDK11B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK11 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-CDK11 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-CDK11 Antibody, Affinity Purified

Predicted Reactivity: Mouse

Purification: Affinity Purified

Immunogen: between AA 730 and C-term

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 to 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CDK11

Target: CDK11 (CDK11B) (Cyclin-Dependent Kinase 11B (CDK11B))

Alternative Name: CDK11

Background: Background: CDK11 is a member of the p34Cdc2 protein kinase family and is involved in cell cycle progression, apoptosis, and tumorigenesis. Many isoforms of CDK11 have been isolated. The p58 isoform has been shown to interact with cyclin D3 and to play an important role in G2/M phase progression. The p110 isoforms have been demonstrated to interact with the RNA-binding proteins RNPS1, RNA polymerase II, and many elongation factors, indicating a role in RNA metabolism in proliferating cells.

Gene ID: 728642

NCBI Accession: NP_001300825

UniProt: Q9UQ88

Pathways: Regulation of Lipid Metabolism by PPARalpha, M Phase