WRNIP1 antibody (AA 400-450)

Catalog No. ABIN7454746

The Rabbit Polyclonal anti-WRNIP1 antibody has been validated for WB, IP and IHC (fp). It is suitable to detect WRNIP1 in samples from Human.

Quick Overview for WRNIP1 antibody (AA 400-450) (ABIN7454746)

Target: WRNIP1 (Werner Helicase Interacting Protein 1 (WRNIP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WRNIP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-WRNIP1 Antibody

Binding Specificity: AA 400-450

Purpose: Rabbit anti-WRNIP1 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat

Purification: Affinity Purified

Immunogen: between AA 400 and 450

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for WRNIP1

Target: WRNIP1 (Werner Helicase Interacting Protein 1 (WRNIP1))

Alternative Name: WRNIP1

Background: Background: WRNIP1 (Werner helicase interacting protein 1) was identified as a protein that interacts with the N-terminal region of Werner protein (WRN). WRN is a RecQ DNA helicase important to DNA repair and is the causative gene of Werner syndrome (WS), an autosomal recessive disease characterized by premature aging. WRNIP1 has been shown to interact with DNA polymerase delta (pol delta) and play a role in pol delta-mediated DNA synthesis. Additionally, WRNIP1 has been shown to interact with polyubiquitin chains indicating a link between ubiquitination and the DNA repair pathway.

Gene ID: 56897

NCBI Accession: NP_064520

UniProt: Q96S55